Green polymer hydrogels from a natural monomer with inherent antioxidative capability for efficient wound healing and spinal cord injury treatment

Author:

Du Jiaqiang1,Wang Fang2,Li Jiaxi2,Yang Yuxuan3,Guo Dong2,Zhang Yanfeng1ORCID,Yang Aimin4,He Xijing25,Cheng Yilong14ORCID

Affiliation:

1. Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, School of Chemistry, Xi'an Jiaotong University, Xi'an 710049, China

2. Department of Orthopaedics, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710049, China

3. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049, China

4. Department of Nuclear Medicine, the First Affiliated Hospital of China, Xi'an Jiaotong University, Xi'an 710049, China

5. Department of Orthopaedics, Xi'an International Medical Center Hospital, Xi'an 710049, China

Abstract

An advanced hydrogel with potent antioxidative capability has been developed by one-step polymerization of α-lipoic acid. The hydrogel can accelerate skin wound healing and spinal cord injury recovery through the regulation of reactive oxygen species.

Funder

National Natural Science Foundation of China

Xi’an Jiaotong University

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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