An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance

Author:

Xiao Ximian12345ORCID,Zhang Si678910ORCID,Chen Sheng678910ORCID,Qian Yuxin678910ORCID,Xie Jiayang678910ORCID,Cong Zihao678910ORCID,Zhang Danfeng678910ORCID,Zou Jingcheng678910ORCID,Zhang Wenjing678910ORCID,Ji Zhemin678910,Cui Ruxin678910ORCID,Qiao Zhongqian678910ORCID,Jiang Weinan678910ORCID,Dai Yidong11125,Wang Yun11125,Shao Xiaoyan11125,Sun Yun11125,Xia Jiang1314155,Fei Jian1617185,Liu Runhui12345ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering

2. School of Materials Science and Engineering

3. East China University of Science and Technology

4. Shanghai 200237

5. China

6. Key Laboratory for Ultrafine Materials of Ministry of Education

7. Frontiers Science Center for Materiobiology and Dynamic Chemistry

8. Research Center for Biomedical Materials of Ministry of Education

9. State Key Laboratory of Molecular Engineering of Polymers (Fudan University)

10. Key Laboratory of Specially Functional Polymeric Materials and Related Technology (ECUST) Ministry of Education

11. Shanghai Ruijin Rehabilitation Hospital

12. Shanghai 200023

13. Department of Chemistry

14. The Chinese University of Hong Kong

15. Hong Kong

16. Department of General Surgery

17. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

18. Shanghai 200025

Abstract

An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.

Funder

National Natural Science Foundation of China

Program of Shanghai Academic Research Leader

National Basic Research Program of China

State Key Laboratory of Bioreactor Engineering

Fundamental Research Funds for the Central Universities

State Key Laboratory of Trauma, Burns and Combined Injury

Shanghai Jiao Tong University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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