In situconversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy

Author:

Hou Rui12345,Liang Xiaolong6745ORCID,Li Xiaoda12345,Zhang Xu12345,Ma Xiaotu8910114,Wang Fan12345

Affiliation:

1. Medical Isotopes Research Center and Department of Radiation Medicine

2. School of Basic Medical Sciences

3. Peking University

4. Beijing

5. China

6. Department of Ultrasound

7. Peking University Third Hospital

8. Key Laboratory of Protein and Peptide Pharmaceuticals

9. CAS Center for Excellence in Biomacromolecules

10. Institute of Biophysics

11. Chinese Academy of Sciences

Abstract

Sonosensitizer microbubbles enhance drug accumulation and the antitumor efficacy of sonodynamic therapy by ultrasound mediated micro to nano conversion.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Ministry of Science and Technology of the People's Republic of China

Beijing Municipal Excellent Talents Foundation

Peking University Third Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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