Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

Author:

Qiu Danye12,Gu Chunfang3,Liu Guizhen1,Ritter Kevin1,Eisenbeis Verena B.1ORCID,Bittner Tamara1,Gruzdev Artiom3,Seidel Lea245,Bengsch Bertram24,Shears Stephen B.3ORCID,Jessen Henning J.12ORCID

Affiliation:

1. Institute of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Freiburg, 79104, Freiburg, Germany

2. CIBSS – Centre for Integrative Biological Signaling Studies, University of Freiburg, Germany

3. Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA

4. Clinic for Internal Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

5. SGBM – Spemann Graduate School of Biology and Medicine, University of Freiburg, Germany

Abstract

Capillary electrophoresis mass spectrometry demonstrates that the inositol pyrophosphates 2-PP-InsP5 and 4- or 6-PP-InsP5 exist in different mammalian tissues in addition to canonical isomers.

Funder

Volkswagen Foundation

Deutsche Forschungsgemeinschaft

National Institute of Environmental Health Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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