An AIE-based monofunctional Pt(<scp>ii</scp>) complex for photodynamic therapy through synergism of necroptosis

An AIE-based monofunctional Pt(ii) complex for photodynamic therapy through synergism of necroptosis–ferroptosis

Published:2024 Issue: Volume: Page:
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Zheng Xiaoxue¹,Liu Minglun¹,Wu Yanping¹,Chen Yuncong¹²^ORCID,He Weijiang¹^ORCID,Guo Zijian¹²^ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China

2. Nanchuang (Jiangsu) Institute of Chemistry and Health, Nanjing 210000, China

Abstract

We report an AIE-based monofunctional Pt(ii) complex with increased singlet oxygen production and negligible dark toxicity. This enters cells via endocytosis, accumulates in lysosomes and produces ROS under light irradiation, causing FSP1-downregulation and cell death by ferroptosis and necroptosis.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D3CB00113J

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