Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>-Reference-Cited by-同舟云学术

Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant Staphylococcus aureus and Mycobacterium tuberculosis

Published:2023 Issue:7 Volume:14 Page:1296-1308
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Ommi Ojaswitha¹,Naiyaz Ahmad Mohammad²³^ORCID,Gajula Siva Nageswara Rao⁴,Wanjari Parita⁴,Sau Shashikanta⁵,Agnivesh Puja Kumari⁵,Sahoo Santosh Kumar⁶^ORCID,Kalia Nitin Pal⁵^ORCID,Sonti Rajesh⁴,Nanduri Srinivas¹^ORCID,Dasgupta Arunava²³,Chopra Sidharth²³^ORCID,Yaddanapudi Venkata Madhavi¹^ORCID

Affiliation:

1. Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad 500037, Telangana, India

2. Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India

3. AcSIR: Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

4. Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad 500037, Telangana, India

5. Department of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad 500037, Telangana, India

6. Department of Pharmaceutical Chemistry, GITAM School of Pharmacy, GITAM University, Visakhapatnam 530045, India

Abstract

One lead compound, 7a, (3,4-dichlorophenyl derivative), exhibited potent activity against S. aureus (MIC = 0.25 μg mL−1), and the other compound, 7j (2,4-difluorophenyl derivative) against Mycobacterium tuberculosis (MIC = 1 μg mL−1) without any appreciable cytotoxicity.

Funder

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00079F

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