Sequential Dieckmann cyclization enables the total synthesis of 7-epi-clusianone and 18-hydroxy-7-epi-clusianone

Author:

Wan Yunhui1,Wu Huaimo1,Xia Linhao1,Liu Song1,Ren Yi1,Xu Hongxi1ORCID,Zheng Changwu1ORCID

Affiliation:

1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China

Abstract

We established a protocol for constructing the core of polycyclic polyprenylated acylphloroglucines. This protocol facilitated the synthesis of 7-epi-clusianone, 18-hydroxy-7-epi-clusianone, and sampsonione P via a 6-membered intermediate.

Funder

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

National Natural Science Foundation of China-Yunnan Joint Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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