Antimicrobial Activity of Metal-containing Dendrimers

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Abstract

In this chapter, we presented a review of the use of transition metal-containing dendrimers as antimicrobial agents. A general background on antimicrobial resistance as a global health threat and its association with antibiotic resistant bacteria was included to demonstrate the need for the development of new and advanced antibacterial agents. Many new transition metal-containing dendrimers as antimicrobial agents were included as examples. The synthetic methodologies and the testing of these new dendrimers in vitro and in vivo were also incorporated in the discussion. Different classes of organic dendrimers containing transition metals were included, such as poly(propylene imine)- and poly(amidoamine)- as well as carbosilane- and phthalocyanine-based dendrimers. Inorganic and organometallic dendrimers like phosphazene-, ferrocene- and cationic cyclopentadienyliron-based dendrimers and their examination as antimicrobial agents were also illustrated. These types of dendrimers have shown a wide range of activities against Gram-positive and Gram-negative bacteria and fungi, as well as bacterial biofilms.

Publisher

The Royal Society of Chemistry

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