Antipseudomonal Therapy and Quorum Quenching: A Prospective Marker

Abstract

Antibiotics have been used excessively to treat Pseudomonas aeruginosa infections around the world, resulting in growing resistance to several antibiotics for this disease. Due to widespread resistance and the present poor efficacy of antibiotics used to treat P. aeruginosa infections, fresh alternative therapeutic techniques for infection therapy are required. Biofilms of P. aeruginosa can cause serious infections, resulting in increased drug resistance and a higher mortality rate among patients. No effective techniques exist for managing these infections, requiring new and effective antibiotic treatments. Quorum sensing (QS) is a promising target for developing non-antibiotic anti-infective drugs. Extracts from medicinal plants contain a variety of secondary metabolites, like phenolics, quinones, flavonoids, alkaloids, terpenoids and polyacetylenes, that can prevent bacterial pathogenicity and have the potential to control microbial diseases. New safe and effective QS inhibitory compounds have sparked interest. As a result, quorum sensing inhibitors (QSIs) or quorum quenching (QQ) methods are now being considered as potential therapeutic alternatives and/or adjuvants to currently failing antibiotics, with the ability to control pathogen virulence traits, allowing the host immune system to quickly eliminate bacteria. The goals of this chapter are to offer a concise explanation of research findings on antipseudomonal therapy and synthetic QSIs for P. aeruginosa, as well as to appraise the current understanding of QS processes and various quorum quenchers (QQs) for P. aeruginosa.