Computer-aided design of short peptide ligands targeting tumor necrosis factor-alpha for adsorbent applications

Author:

Chen Jie12345ORCID,Sun Jixue12345,Han Wenyan12345,Chen Jian12345,Wang Weichao12345ORCID,Cheng Guanghui12345,Lin Jianping12345,Ma Nan6789,Chen Hao1011121314,Ou Lailiang12345ORCID,Li Wenzhong1011121314

Affiliation:

1. Key Laboratory of Bioactive Materials

2. Ministry of Education

3. College of Life Sciences

4. Nankai University

5. Tianjin

6. Department of Cardiac Surgery

7. University of Rostock

8. D-18057 Rostock

9. Germany

10. School of Ophthalmology & Optometry

11. Eye Hospital

12. School of Biomedical Engineering

13. Wenzhou Medical University

14. Wenzhou

Abstract

A peptide ligand (T1: Ac-RKEM-NH2) designed by a computer-aided method can enhance TNF-α adsorption from the plasma of rats with sepsis to PVA.

Funder

National Natural Science Foundation of China

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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