A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis

Author:

Ge Ting1,Weiwei Zhang1ORCID,Ge Fei1,Zhu Longbao1,Song Ping1,Li Wanzheng1,Gui Lin2,Dong Wan1,Tao Yugui1ORCID,Yang Kai3ORCID

Affiliation:

1. School of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, People's Republic of China

2. Department of Microbiology and Immunology, Wannan Medical College, Wuhu, Anhui 241002, People's Republic of China

3. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu, China

Abstract

Synthesis of 5-Fu/ICG@ZIF-90-PEG-ZOL. Design based on bone-targeted modification on the surface of nanocarrier with ZOL, and also in combination chemotherapy and photothermal therapy (created in BioRender.com).

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Province

Anhui Polytechnic University

Anhui University

Wannan Medical College

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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