Synthesis, Properties, and Biological Applications of Thiopyrans

Abstract

Within the realm of heterocyclic compounds, thiopyrans stand out as a subclass with a distinctive six-membered ring encompassing a single sulfur atom. They are analogous to pyrans, in which the oxygen atom is replaced by a sulfur atom. There are two isomeric variations—2H-thiopyran and 4H-thiopyran—based on the arrangement of double bonds. In the fields of organic chemistry and drug discovery, this class of compounds plays a crucial role due to their broad spectrum of physiological functions. They are integral components of a variety of natural products and pharmaceutical agents. The invaluable role of thiopyrans in drug discovery is attributed to their diverse array of physiological functions. A significant research interest has been prevalent in thiopyran derivatives, which have been explored for their potential therapeutic applications. The pharmacological spectrum of thiopyran analogs encompasses antibacterial, antifungal, anti-inflammatory, antiviral, antidiabetic, and anticancer properties. Thiopyran derivatives, with their inherent variety of activities, have garnered attention among researchers as a promising field of research for the discovery of novel molecules. Current research endeavors persist in delving into the potential applications and properties of thiopyran compounds and their derivatives. In this chapter, the syntheses and pharmacological applications of thiopyran derivatives will be discussed.