Oncosis-inducing cyclometalated iridium(iii) complexes-Reference-Cited by-同舟云学术

Oncosis-inducing cyclometalated iridium(iii) complexes

Published:2018 Issue:23 Volume:9 Page:5183-5190
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guan Ruilin¹²³⁴⁵,Chen Yu¹²³⁴⁵,Zeng Leli¹²³⁴⁵^ORCID,Rees Thomas W.¹²³⁴⁵,Jin Chengzhi¹²³⁴⁵,Huang Juanjuan¹²³⁴⁵,Chen Zhe-Sheng⁶⁷⁸⁹^ORCID,Ji Liangnian¹²³⁴⁵,Chao Hui¹²³⁴⁵^ORCID

Affiliation:

1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

2. School of Chemistry

3. Sun Yat-Sen University

4. Guangzhou

5. P. R. China

6. College of Pharmacy and Health Sciences

7. St. John's University

8. New York

9. USA

Abstract

A series of mitochondria-targeting cyclometalated iridium(iii) complexes activated the oncosis-specific protein porimin and calpain 1, and exhibited good inhibitory activities on a wide range of cancer types including drug-resistant cancers.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC01142G

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