Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats

Author:

Ahmed Hanan H.1ORCID,Essam Reham M.23ORCID,El-Yamany Muhammed F.2,Ahmed Kawkab A.4ORCID,El-Sahar Ayman E.23ORCID

Affiliation:

1. Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo, University, Cairo, Egypt

3. Biology Department, School of Pharmacy, Newgiza University, Giza, Egypt

4. Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

Abstract

The effects of CRS on inducing depression and the beneficial effect of LF in halting depression through mitigating ROS and pro-inflammatory cytokines, restoring corticosterone, 5-HT and BDNF levels, and modulating the hippocampal PI3K/Akt/mTOR/GSK-3β pathway were studied.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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