Mobility capillary electrophoresis–native mass spectrometry reveals the dynamic conformational equilibrium of calmodulin and its complexes-Reference-Cited by-同舟云学术

Mobility capillary electrophoresis–native mass spectrometry reveals the dynamic conformational equilibrium of calmodulin and its complexes

Published:2024 Issue:14 Volume:149 Page:3793-3802
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Zhao Yi¹,Zhang Wenjing¹^ORCID,Hong Jie²,Yang Lei¹^ORCID,Wang Yuanyuan³,Qu Feng⁴,Xu Wei¹^ORCID

Affiliation:

1. School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China

2. Kunshan Nier Precision Instrumentation Inc. Kunshan, Suzhou, 215316, China

3. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China

4. School of Life Science, Beijing Institute of Technology, Beijing 100081, China

Abstract

Instead of possessing a fixed conformation, it is found that a calmodulin molecule actually jumps between two very distinct conformations. The binding of Ca2+ metal ions did not affect the structural dynamics of calmodulin.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D4AN00378K

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