Evaluation of gelatin-based hydrogels for colon and pancreas studies using 3D <i>in vitro</i> cell culture-Reference-Cited by-同舟云学术

Evaluation of gelatin-based hydrogels for colon and pancreas studies using 3D in vitro cell culture

Published:2024 Issue:12 Volume:12 Page:3144-3160
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Pamplona Regina¹^ORCID,González-Lana Sandra²³^ORCID,Ochoa Ignacio³⁴⁵^ORCID,Martín-Rapún Rafael¹⁴⁶^ORCID,Sánchez-Somolinos Carlos⁴⁷^ORCID

Affiliation:

1. Aragón Institute of Nanoscience and Materials (INMA), CSIC-University of Zaragoza, Department of Organic Chemistry, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain

2. BEONCHIP S.L., CEMINEM, Campus Río Ebro. C/Mariano Esquillor Gómez s/n, 50018 Zaragoza, Spain

3. Tissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, C/Mariano Esquillor s/n, 500018 Zaragoza, Spain

4. CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain

5. Institute for Health Research Aragón (IIS Aragón), Paseo de Isabel La Católica 1-3, 50009 Zaragoza, Spain

6. Universidad de Zaragoza, Facultad de Ciencias, Departamento de Química Orgánica, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain

7. Aragón Institute of Nanoscience and Materials (INMA), CSIC-University of Zaragoza, Department of Condensed Matter Physics (Faculty of Science), C/Pedro Cerbuna 12, 50009 Zaragoza, Spain

Abstract

GelMA-based hydrogels with tunable stiffness through two crosslinking strategies and diverse swelling behavior, are evaluated as potential 3D models for CRC and pancreatic cancer. Stiffness and composition influence cell proliferation and migration.

Funder

European Social Fund Plus

Agencia Estatal de Investigación

Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina

European Regional Development Fund

Gobierno de Aragón

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02640J

Reference77 articles.

1. Mechanotransduction in cancer

2. Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

3. Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

4. Actomyosin stress fiber mechanosensing in 2D and 3D

5. An interplay of matrix stiffness, dimensionality and adhesivity on cellular behavior