Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake-Reference-Cited by-同舟云学术

Anti-PEG antibodies enriched in the protein corona of PEGylated nanocarriers impact the cell uptake

Published:2023 Issue:10 Volume:8 Page:1377-1385
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Deuker Mareike F. S.¹,Mailänder Volker²¹,Morsbach Svenja¹^ORCID,Landfester Katharina¹^ORCID

Affiliation:

1. Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany

2. Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany

Abstract

Anti-PEG antibodies present in blood samples of German donors were found to be enriched in the protein corona of PEGylated nanocarriers. This enrichment led to enhanced uptake in macrophages, counteracting the desired stealth effect of PEG.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NH/D3NH00198A

Reference51 articles.

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5. Effects of pharmaceutical PEGylation on drug metabolism and its clinical concerns

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