A micro-flow rapid dual activation approach for urethane-protected α-amino acid <i>N</i>-carboxyanhydride synthesis-Reference-Cited by-同舟云学术

A micro-flow rapid dual activation approach for urethane-protected α-amino acid N-carboxyanhydride synthesis

Published:2022 Issue:16 Volume:20 Page:3303-3310
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Okabe Ren¹,Sugisawa Naoto¹,Fuse Shinichiro¹^ORCID

Affiliation:

1. Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan

Abstract

A variety of urethane-protected α-amino acid N-carboxyanhydrides (UNCAs) were synthesized in high yields via the rapid dual activation of both an α-NCA and alkyl chloroformate by combination of two amines in a micro-flow reactor.

Funder

Japan Society for the Promotion of Science

Nagoya University

Japan Science and Technology Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00167E

Reference79 articles.

1. Synergistic catalysis: A powerful synthetic strategy for new reaction development

2. Combining transition metal catalysis and organocatalysis – an update

3. Combinations of Aminocatalysts and Metal Catalysts: A Powerful Cooperative Approach in Selective Organic Synthesis

4. Cooperative bimetallic catalysis in asymmetric allylic substitution

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