Macrophage-derived nanovesicles exert intrinsic anti-inflammatory properties and prolong survival in sepsis through a direct interaction with macrophages

Author:

Molinaro Roberto12345ORCID,Pastò Anna12346,Corbo Claudia12347ORCID,Taraballi Francesca89104,Giordano Federica12348,Martinez Jonathan O.12348,Zhao Picheng11234,Wang Xin12348,Zinger Assaf12348,Boada Christian12348ORCID,Hartman Kelly A.12348,Tasciotti Ennio12348

Affiliation:

1. Center for Biomimetic Medicine

2. Houston Methodist Research Institute

3. Houston

4. USA

5. School of Pharmacy

6. Veneto Institute of Oncology IOV – IRCCS

7. School of Medicine and Surgery

8. Houston Methodist Orthopedic and Sports Medicine

9. Houston Methodist Hospital

10. 6565 Fannin Street Houston

11. Department of Pathology and Genomic Medicine

Abstract

Here, we have demonstrated that biomimetic nanovesicles assembled from macrophages' membrane proteins are similar to macrophage-derived exosomes. The anti-inflammatory activity observed in vivo derives from their direct interaction with macrophages.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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