Zwitterion-functionalized hollow mesoporous Prussian blue nanoparticles for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia

Author:

Bai Huiyuan12345,Sun Quanhao12345,Kong Fei12345,Dong Haijiao12345,Ma Ming12345,Liu Fangzhou678,Wang Chen9108ORCID,Xu Haiyan11128ORCID,Gu Ning12345,Zhang Yu12345ORCID

Affiliation:

1. State Key Laboratory of Bioelectronics

2. Jiangsu Key Laboratory for Biomaterials and Devices

3. School of Biological Science and Medical Engineering and Collaborative

4. Innovation Center of Suzhou Nano Science and Technology

5. Southeast University

6. Department of Head & Neck Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University

7. Nanjing 210029

8. P. R. China

9. National Center for Nanoscience and Technology

10. Beijing 100190

11. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College

12. Beijing 100005

Abstract

Illustration of HMPBs(DNR + AraC)@PEI-ZS-E5 for targeted and synergetic chemo-photothermal treatment of AML. The nanoplatform showed excellent photothermal effects, reduced protein adsorption and remarkable targeting/chemo/photothermal effects.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Support Project of Jiangsu Province

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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