A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action-Reference-Cited by-全球学者库

A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action

Published:2014 Issue:7 Volume:5 Page:2761-2770
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Zhou Wen¹²³⁴,Wang Xiaoyong⁵⁶⁷³⁴,Hu Ming¹²³⁴,Zhu Chengcheng¹²³⁴,Guo Zijian¹²³⁴

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Nanjing University

4. Nanjing 210093, P. R. China

5. State Key Laboratory of Pharmaceutical Biotechnology

6. School of Life Sciences

7. State Key Laboratory of Analytical Chemistry for Life Science

Abstract

A cationic copper complex with triphenylphosphine as a targeting group preferentially accumulates in mitochondria of tumor cells and strongly inhibits their proliferation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC00384E

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