Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

Author:

Ma Yue12345ORCID,Frutos-Beltrán Estrella678,Kang Dongwei12345ORCID,Pannecouque Christophe9101112,De Clercq Erik9101112ORCID,Menéndez-Arias Luis678ORCID,Liu Xinyong12345,Zhan Peng12345

Affiliation:

1. Department of Medicinal Chemistry

2. Key Laboratory of Chemical Biology

3. Ministry of Education

4. School of Pharmaceutical Sciences

5. Shandong University

6. Centro de Biología Molecular “Severo Ochoa” (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid)

7. Madrid

8. Spain

9. Rega Institute for Medical Research

10. K. U. Leuven

11. B-3000 Leuven

12. Belgium

Abstract

This review summarizes current advances in medicinal chemistry aimed at the discovery of antiviral compounds specifically targeted against drug-resistant strains.

Funder

National Natural Science Foundation of China

Consejo Superior de Investigaciones Científicas

Key Technology Research and Development Program of Shandong

Ministerio de Ciencia, Innovación y Universidades

Fundación Ramón Areces

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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