Sensitizing chemotherapy for glioma with fisetin mediated by a microenvironment-responsive nano-drug delivery system

Author:

Wang Wanyu1,Zhang Yuanyuan2,Jian Yue1,He Shi1,Liu Jiagang1,Cheng Yongzhong1,Zheng Songping1,Qian Zhiyong1ORCID,Gao Xiang1ORCID,Wang Xiang1ORCID

Affiliation:

1. Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, PR China

2. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Abstract

In this work, we designed a microenvironment-responsive nano-delivery system to enhance the therapeutic effect of chemotherapy, which provided a feasible scheme to solve drug resistance and achieve targeted therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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