Unraveling molecular mechanisms of β-glucuronidase inhibition by flavonoids from Centaurea scoparia: integrated in silico and in vitro insights-Reference-Cited by-同舟云学术

Unraveling molecular mechanisms of β-glucuronidase inhibition by flavonoids from Centaurea scoparia: integrated in silico and in vitro insights

Published:2024 Issue:32 Volume:48 Page:14236-14252
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Alwaili Maha A.¹,Aba Alkhayl Faris F.²,Rudayni Hassan A.³,Allam Ahmed A.³⁴,Altoom Naif G.⁵,Lamsabhi Al Mokhtar⁶⁷^ORCID,Kamel Emadeldin M.⁸^ORCID

Affiliation:

1. Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, Riyadh 11671, Saudi Arabia

2. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia

3. Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia

4. Department of Zoology, Faculty of Science, Beni-suef University, Beni-suef 65211, Egypt

5. Department of Biology, King Khalid Military Academy, Riyadh 11459, Saudi Arabia

6. Departamento de Química, Módulo 13, Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC Cantoblanco, 28049 Madrid, Spain

7. Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

8. Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt

Abstract

Investigating the detailed molecular mechanisms of β-glucuronidase inhibition is critical for pioneering new therapeutic solutions and driving progress in pharmaceutical research.

Funder

Princess Nourah Bint Abdulrahman University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D4NJ02393E

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5. Unveiling the tyrosinase inhibitory potential of phenolics from Centaurium spicatum: Bridging in silico and in vitro perspectives