Dual targeting nanoparticles for epilepsy therapy

Author:

Hou Qinghong123,Wang Lulu4,Xiao Feng1,Wang Le1,Liu Xiaoyan1,Zhu Lina3ORCID,Lu Yi4,Zheng Wenfu2,Jiang Xingyu1ORCID

Affiliation:

1. Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, P. R. China

2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China

3. Department of Chemistry, School of Science, Tianjin University, Tianjin 300350, P. R. China

4. CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, P. R. China

Abstract

Dual-targeting nanoparticles containing D-T7 peptide and Tet1 peptide were designed for carrying lamotrigine (LTG) to cross the blood–brain barrier and further concentrate at the epilepsy lesions for treating epilepsy with high biosafety.

Funder

Shenzhen Bay Laboratory

National Natural Science Foundation of China

Chinese Academy of Sciences

Guangdong Innovative and Entrepreneurial Research Team Program

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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