Discovery and heterologous biosynthesis of glycosylated polyketide luteodienoside A reveals unprecedented glucinol-mediated product offloading by a fungal carnitine <i>O</i>-acyltransferase domain-Reference-Cited by-同舟云学术

Discovery and heterologous biosynthesis of glycosylated polyketide luteodienoside A reveals unprecedented glucinol-mediated product offloading by a fungal carnitine O-acyltransferase domain

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Arishi Amr A.¹²^ORCID,Shang Zhuo¹³^ORCID,Lacey Ernest⁴⁵^ORCID,Crombie Andrew⁵^ORCID,Vuong Daniel⁵^ORCID,Li Hang¹⁶^ORCID,Bracegirdle Joe¹^ORCID,Turner Peter⁷,Lewis William⁷^ORCID,Flematti Gavin R.¹^ORCID,Piggott Andrew M.⁴^ORCID,Chooi Yit-Heng¹^ORCID

Affiliation:

1. School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia

2. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

3. School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, China

4. School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia

5. Microbial Screening Technologies Pty. Ltd, Smithfield, NSW 2164, Australia

6. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

7. School of Chemistry, The University of Sydney, NSW 2006, Australia

Abstract

Luteodienoside A – a glycosylated polyketide produced by the Australian fungus Aspergillus luteorubrus is biosynthesised by a polyketide synthase with a carnitine O-acyltransferase domain capable of adding glucinol to the polyketide product.

Funder

Australian Research Council

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05008D

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