Spatial confinement of chemically engineered cancer cells using large graphene oxide sheets: a new mode of cancer therapy

Author:

Chen Tianshu12,Zhang Qianqian3,Song Yuchen3,Isak Albertina N3,Tang Xiaochen12,Wang Hao4,Ma Zhongliang3,Sun Fenyong4,Pan Qiuhui12,Zhu Xiaoli4ORCID

Affiliation:

1. Department of Clinical Laboratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China

2. Shanghai Key Laboratory of Clinical Molecular Diagnostics for Pediatrics, Shanghai 200127, P. R. China

3. School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

4. Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, P. R. China

Abstract

A concept of cancer treatment is developed by imposing large graphene oxide sheets as a “cage” on cancer cells to limit their spatial behavior through the inhibition of cell migration and invasion, which directly addresses the defining trait of cancer on the cellular level.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

Shanghai Shenkang Hospital Development Center

Program of Shanghai Academic Research Leader

Shanghai Municipal Health Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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