Synthesis of fluorinated leucines, valines and alanines for use in protein NMR-Reference-Cited by-同舟云学术

Synthesis of fluorinated leucines, valines and alanines for use in protein NMR

Published:2022 Issue:12 Volume:20 Page:2424-2432
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Maleckis Ansis¹^ORCID,Abdelkader Elwy H.²^ORCID,Herath Iresha D.²,Otting Gottfried²^ORCID

Affiliation:

1. Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia

2. ARC Centre of Excellence for Innovations in Peptide & Protein Science, Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia

Abstract

19F-NMR spectra of the protein GB1 produced by cell-free protein synthesis with fluorinated amino acids substituting their canonical parent amino acids show exceptionally large chemical shift dispersions, which indicate structural conservation.

Funder

Australian Research Council

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00145D

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4. S.Vukelić , J.Moschner , S.Huhmann , R.Fernandes , A. A.Berger and B.Koksch , in Modern Synthesis Processes and Reactivity of Fluorinated Compounds , Elsevier , 2017 , p. 427

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