Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system-Reference-Cited by-同舟云学术

Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system

Published:2022 Issue:13 Volume:12 Page:4312-4324
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Borowiecki Paweł¹^ORCID,Rudzka Aleksandra¹^ORCID,Reiter Tamara²,Kroutil Wolfgang²^ORCID

Affiliation:

1. Laboratory of Biocatalysis and Biotransformation, Department of Drugs Technology and Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Koszykowa St. 75, 00-662 Warsaw, Poland

2. Institute of Chemistry, University of Graz, NAWI Graz, BioTechMed Graz, Field of Excellence BioHealth, Heinrichstrasse 28, 8010 Graz, Austria

Abstract

This article reports on a novel biocatalytic method for the synthesis of both enantiomers of lisofylline based on Trametes versicolor laccase, TEMPO as a redox mediator and stereocomplementary recombinant alcohol dehydrogenases as biocatalysts.

Funder

Narodowe Centrum Nauki

Politechnika Warszawska

Karl-Franzens-Universität Graz

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CY/D2CY00145D

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1. PK/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response