Discovery of new chiral sulfonamides bearing benzoxadiazole as HIF inhibitors for non-small cell lung cancer therapy: design, microwave-assisted synthesis, binding affinity, in vitro antitumoral activities and in silico studies-Reference-Cited by-同舟云学术

Discovery of new chiral sulfonamides bearing benzoxadiazole as HIF inhibitors for non-small cell lung cancer therapy: design, microwave-assisted synthesis, binding affinity, in vitro antitumoral activities and in silico studies

Published:2022 Issue:6 Volume:46 Page:2777-2791
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Kahraman Demet Taşdemir¹²^ORCID,Karaküçük-İyidoğan Ayşegül³,Saygideger Yasemin⁴⁵⁶^ORCID,Oruç-Emre Emine Elçin³^ORCID,Taskin-Tok Tugba³⁷,Başaran Eyüp³⁸^ORCID,İlhan Sedat²,Demir Burcu Saygıdeğer⁹,Üren Aykut⁶,Bayram Hasan¹⁰¹¹

Affiliation:

1. Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry, Cell Culture Laboratory, Gaziantep, Turkey

2. Gaziantep University, Institute of Health Sciences, Department of Respiratory Biology, Gaziantep, Turkey

3. Gaziantep University, Faculty of Science and Arts, Department of Chemistry, Gaziantep, Turkey

4. Department of Chest Diseases, Cukurova University School of Medicine, Adana, Turkey

5. Department of Translational Medicine, Institute of Health Sciences, Cukurova University, Adana, Turkey

6. Georgetown University, Department of Oncology, Washington DC, USA

7. Gaziantep University, Institute of Health Sciences, Department of Bioinformatics and Computational Biology, Gaziantep, Turkey

8. Batman University, Department of Chemistry and Chemical Processing Technologies, Batman, Turkey

9. Department of Biotechnology, Institute of Natural and Applied Sciences, Cukurova University, Adana, Turkey

10. Gaziantep University, Faculty of Medicine, Department of Pulmonary Diseases, Gaziantep, Turkey

11. Koç University, School of Medicine, Department of Pulmonary Medicine, Koç University Research Center for Translational Medicine (KUTTAM), İstanbul, Turkey

Abstract

Thirty-four chiral compounds having benzoxadiazole and sulfonamide moieties on the skeleton have been synthesized. The in vitro cytotoxic activity and apoptotic effects of these compounds have been evaluated using the A549 lung cancer cell line.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ03809E

Reference62 articles.

1. Cancer prevention from the perspective of global cancer burden patterns

2. Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells

3. Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy

4. Prognosis value of HIF-1α expression in patients with non-small cell lung cancer

5. TR3 is involved in hypoxia-induced apoptosis resistance in lung cancer cells downstream of HIF-1α

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