Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol inPsoralea corylifolia L.-Reference-Cited by-同舟云学术

Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol inPsoralea corylifolia L.

Published:2017 Issue:83 Volume:7 Page:52661-52671
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yao Zhihong¹²³⁴⁵^ORCID,Li Shishi¹²³⁴,Qin Zifei¹²³⁴⁵^ORCID,Hong Xiaodan¹²³⁴⁶,Dai Yi¹²³⁴⁵,Wu Baojian¹²³⁴⁵,Ye Wencai¹²³⁴⁵^ORCID,Gonzalez Frank J.⁷⁸⁹¹⁰¹¹,Yao Xinsheng¹²³⁴⁵^ORCID

Affiliation:

1. College of Pharmacy

2. Jinan University

3. Guangzhou 510632

4. P. R. China

5. Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

6. Guangzhou Research and Creativity Biotechnology Co. Ltd

7. Laboratory of Metabolism

8. Center for Cancer Research

9. National Cancer Institute

10. National Institutes of Health

11. Bethesda

Abstract

Norbakuchinic acid (NBKA) is the most abundant metabolite of bakuchiol (a hepatotoxicity and nephrotoxicity component inPsoralea corylifoliaL.) in plasma and urine.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA10376J

Reference48 articles.

1. The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review

2. Simultaneous and highly sensitive quantification of five bioactive components in Fructus Psoraleae and in rat plasma by HPLC with fluorescence detection

3. Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague–Dawley rats