Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

Author:

Kim Suhyeon123ORCID,Ga Seongmin23ORCID,Bae Hayeon23ORCID,Sluyter Ronald4ORCID,Konstantinov Konstantin1ORCID,Shrestha Lok Kumar56ORCID,Kim Yong Ho237ORCID,Kim Jung Ho1ORCID,Ariga Katsuhiko58ORCID

Affiliation:

1. Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, Squires Way, North Wollongong, NSW 2500, Australia

2. SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea

3. Department of Nano Science and Technology, Sungkyunkwan University (SKKU), Suwon, Republic of Korea

4. Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia

5. Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan

6. Department of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1, Tennodai, 305-8573 Tsukuba, Ibaraki, Japan

7. Department of Nano Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea

8. Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8561, Japan

Abstract

This article reviews the integration of multidisciplinary approaches, including protein engineering, computational biology, and nanoarchitectonics, to advance pharmaceutical enzyme biocatalysis.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

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