A NIR-driven green affording-oxygen microrobot for targeted photodynamic therapy of tumors

Author:

Zhang Lishan1,Zhang Xiaoting1,Ran Hui1,Chen Ze2,Ye Yicheng1,Jiang Jiamiao1,Hu Ziwei1,Azechi Miral1,Peng Fei3ORCID,Tian Hao1,Xu Zhili4,Tu Yingfeng1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

2. Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China

3. School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China

4. Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China

Abstract

The NIR-driven green affording-oxygen microrobot (CurNPs-C) consists of curcumin-loaded nanoparticles and Chlorella. Under two NIR treatments, CurNPs-C accumulates in tumors and further produces oxygen, which enhances the photodynamic therapy.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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