Photo-crosslinked integrated triphasic scaffolds with gradient composition and strength for osteochondral regeneration

Author:

Wang Wenzhao12ORCID,Li Hui3,Song Ping2,Guo Yanbo4,Luo Di4,Li Hao25,Ma Liang467ORCID

Affiliation:

1. Department of Orthopedics, Qilu Hospital of Shandong University, Shandong University, Jinan, China

2. Orthopedic Research Institute, Department of Orthopedic, West China Hospital, Sichuan University, Chengdu, China

3. Department of Operating Room, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

4. Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

5. Department of Joint Surgery, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

6. Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Science, Jinan, China

7. Post-doctoral Station of Shandong University of Traditional Chinese Medicine, Jinan, China

Abstract

A triphasic GELMA based scaffold was used for osteochondral repair. The upper layer was bonded with chondroitin sulfate, the middle and lower layers introduced hydroxyapatite, promoting chondrogenic, angiogenic and osteogenic induction capabilities.

Funder

Natural Science Foundation of Shandong Province

China Postdoctoral Science Foundation

Key Technology Research and Development Program of Shandong Province

Taishan Scholar Project of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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