Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells
Author:
Affiliation:
1. Department of Pharmacology
2. Nanjing Medical University
3. Nanjing
4. China
5. Maternity and Child Care Center of Xinyu
6. Jiangxi
7. Jiangsu Key Laboratory of Carcinogenesis and Intervention
8. China Pharmaceutical University
9. Nanjing 210009
Abstract
Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells.
Publisher
Oxford University Press (OUP)
Subject
Health, Toxicology and Mutagenesis,Toxicology
Link
http://pubs.rsc.org/en/content/articlepdf/2015/TX/C4TX00239C
Reference64 articles.
1. Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
2. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
3. CYTOCHROME P-450 3A4: Regulation and Role in Drug Metabolism
4. Phthalate Induction of CYP3A4 is Dependent on Glucocorticoid Regulation of PXR Expression
5. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
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