LHRH conjugated gold nanoparticles assisted efficient ovarian cancer targeting evaluated via spectral photon-counting CT imaging: a proof-of-concept research

Author:

Kumar Dhiraj12ORCID,Moghiseh Mahdieh34ORCID,Chitcholtan Kenny2,Mutreja Isha5ORCID,Lowe Chiara34,Kaushik Ajeet6ORCID,Butler Anthony34ORCID,Sykes Peter2,Anderson Nigel3,Raja Aamir37ORCID

Affiliation:

1. Division of Pediatrics Dentistry, School of Dentistry, University of Minnesota, 515 Delaware St SE, Minneapolis, Minnesota, 55455, USA

2. Department of Obstetrics and Gynaecology, Christchurch Women Hospital, University of Otago Christchurch, 2 Riccarton Ave, School of Medicine, Christchurch, New Zealand

3. Department of Radiology, University of Otago Christchurch, 2 Riccarton Ave, School of Medicine, Christchurch, New Zealand

4. MARS Bioimaging Limited, Christchurch, New Zealand

5. Minnesota Dental Research Center for Biomaterials and Biomechanics (MDRCBB), School of Dentistry, University of Minnesota, 515 Delaware St SE, Minneapolis, Minnesota, 55455, USA

6. NanoBiotech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, FL, 33805, USA

7. Department of Physics, Khalifa University, Abu Dhabi, United Arab Emirates

Abstract

Emerging multifunctional nanoparticulate formulations take advantage of nano-meter scale size and surface chemistry to work as a therapeutic delivery agent and a diagnostic tool for non-invasive real-time monitoring using SPCCT imaging technology.

Funder

Cancer Society of New Zealand

Otago School of Medical Sciences

Cancer Research Trust New Zealand

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference80 articles.

1. Cancer statistics, 2022

2. Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

3. R.Narozniak , American Cancer Society 2021 Statistics Report Shows Continuous Decline in Cancer Mortality Rate, Illuminates Disease-Specific Trends - Hematology Advisor, https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/american-cancer-society-2021-statistics-show-continuous-decline/ , (accessed 11 August 2022)

4. Racial and Ethnic Variation in PSA Testing and Prostate Cancer Incidence Following the 2012 USPSTF Recommendation

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