Caffeic acid attenuates the angiogenic function of hepatocellular carcinoma cells via reduction in JNK-1-mediated HIF-1α stabilization in hypoxia-Reference-Cited by-同舟云学术

Caffeic acid attenuates the angiogenic function of hepatocellular carcinoma cells via reduction in JNK-1-mediated HIF-1α stabilization in hypoxia

Published:2016 Issue:86 Volume:6 Page:82774-82782
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Gu Weiting¹²³⁴⁵,Yang Ye⁶⁷²³⁴,Zhang Chi⁸⁹³⁴⁵,Zhang Yujia¹²³⁴⁵,Chen Lijun⁶⁷²³⁴,Shen Jian⁸⁹³⁴⁵,Li Guiying⁶⁷²³⁴,Li Zhong¹²³⁴⁵,Li Lei⁶⁷²³⁴,Li Yuan¹²³⁴⁵,Dong Huibin⁶⁷²³⁴

Affiliation:

1. Department of Nutrition and Food Hygiene

2. School of Public Health

3. Nanjing Medical University

4. Nanjing

5. China

6. The Key Laboratory of Modern Toxicology

7. Ministry of Education

8. Department of General Surgery

9. The Second Affiliated Hospital

Abstract

Our study revealed a novel mechanism in the CaA-attenuated angiogenic ability in HCC cells possiblyviareducing the JNK-1-mediated HIF-1α stabilization and inducing the ubiquitination-mediated HIF1α degradation.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA07703J

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3. Hepatocellular carcinoma with extrahepatic metastasis