Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer-Reference-Cited by-全球学者库

Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer

Published:2021 Issue:4 Volume:6 Page:319-329
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Liu Yun¹²³⁴^ORCID,Tiruthani Karthik⁵⁶³⁴^ORCID,Wang Menglin¹²³⁴^ORCID,Zhou Xuefei¹²³⁴,Qiu Nasha¹²³⁴^ORCID,Xiong Yang¹²³⁴,Pecot Chad V.⁷⁸⁶³⁴,Liu Rihe⁵⁶³⁴⁹,Huang Leaf¹²³⁴^ORCID

Affiliation:

1. Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery

2. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

3. Chapel Hill

4. USA

5. Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy

6. University of North Carolina at Chapel Hill

7. UNC Lineberger Comprehensive Cancer Center

8. School of Medicine

9. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill

Abstract

In breast cancer model, we identified C–C Motif Chemokine Ligand 2 (CCL2) as the key mediator which is secreted by tumor associated adipocytes, and developed targeted lipid-protamine-DNA (LPD) nanoparticles to locally “trap” CCL2 to ameliorate the immunosuppressive tumor microenvironment.

Funder

Foundation for the National Institutes of Health

Eshelman Institute for Innovation, University of North Carolina

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NH/D0NH00588F

Reference26 articles.

1. Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer

2. Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies