Piperlongumine, a <i>Piper longum</i>-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis <i>via</i> suppression of p38 and JNK signaling-Reference-Cited by-同舟云学术

Piperlongumine, a Piper longum-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis via suppression of p38 and JNK signaling

Published:2024 Issue:4 Volume:15 Page:2154-2169
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Luo Na¹²,Zhang Lei²,Xiu Chunmei¹,Luo Xi²,Hu Siyuan²,Ji Kaizhong¹,Liu Qingbai³,Chen Jianquan¹²^ORCID

Affiliation:

1. Department of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, 51 Huzhou Street, Gongshu District, Hangzhou, Zhejiang 310015, China

2. Orthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China

3. Department of Orthopaedics, Lianshui County People's Hospital, The Affiliated Lianshui County People's Hospital of Kangda College of Nanjing Medical University, Huai'an, Jiangsu, China

Abstract

Piperlongumine (PLM), an amide alkaloid derived from Piper longum, exhibits anti-osteoporosis effects by inhibiting RANKL-induced osteoclast differentiation through suppressing p38/JNK-cFos-NFATc1 signaling cascade.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO03830K

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