Medicinal chemistry approaches to target the MNK–eIF4E axis in cancer-Reference-Cited by-同舟云学术

Medicinal chemistry approaches to target the MNK–eIF4E axis in cancer

Published:2023 Issue:6 Volume:14 Page:1060-1087
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Fernandez Ann¹,Monsen Paige J.¹,Platanias Leonidas C.²³⁴,Schiltz Gary E.¹²⁵^ORCID

Affiliation:

1. Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA

2. Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA

3. Division of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA

4. Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, 60612, USA

5. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA

Abstract

Cap-dependent translation can become defective and lead to aberrant oncogenic translation and uncontrolled proliferation. We discuss the functions of MNK and eIF4E and recent medicinal chemistry to develop small molecules to target this axis.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00121K

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