Chalcone derivatives' interaction with human serum albumin and cyclooxygenase-2

Author:

Karthikeyan Subramani1,Thirunarayanan Ayyavu2,Shano Leon Bernet3,Hemamalini Arasappan4,Sundaramoorthy Anandh5,Mangaiyarkarasi Rajendiran6,Abu Norhidayah7ORCID,Ganesan Singaravelu5,Chinnathambi Shanmugavel8ORCID,Pandian Ganesh N.8

Affiliation:

1. Centre for Healthcare Advancement, Innovation and Research, Vellore Institute of Technology, Chennai, 600 127, India

2. Department of Chemical Engineering Biotechnology and Materials, FCFM, University of Chile, Av. Beauchef 851, Santiago, Chile

3. Division of Physics, School of Advanced Sciences, Vellore Insititute of Technology (VIT) Chennai Campus, Vandalur-Kelambakkam Road, Tamil Nadu 600127, India

4. Department of Chemistry, Government College of Engineering Srirangam, Sethurapatti, Thiruchirappalli, Tamil Nadu, India

5. Department of Medical Physics, Anna University, Chennai-600 025, India

6. Centre for Nanotechnology Research, Vellore Institute of Technology, Vellore, Tamil Nadu, India

7. Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia

8. Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, 616-8510, Japan

Abstract

In this study, various spectroscopic and computational techniques were utilized to investigate how new chalcone derivatives bind with cyclooxygenase-2 (COX-2) and Human Serum Albumin (HSA).

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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