A sensitive and cost-effective LC-ESI-MS/MS method for quantitation of euscaphic acid in rat plasma using optimized formic acid concentration in the mobile phase
Author:
Affiliation:
1. School of Pharmacy
2. Hainan Medical University
3. Haikou 571101, China
4. Hainan Provincial Key Laboratory of R&D of Tropical Herbs
Abstract
Formic acid (0.1–0.2‰) in the mobile phase overcame the matrix effects and increased the sensitivity of MS detection of euscaphic acid.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Engineering,General Chemical Engineering,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/AY/C4AY01894J
Reference29 articles.
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2. Triterpene Acids from Euscaphis japonica and Assessment of Their Cytotoxic and Anti-NO Activities
3. Cytotoxic Hexacyclic Triterpene Acids from Euscaphis japonica
4. Simultaneous determination of corosolic acid and euscaphic acid in the plasma of normal and diabetic rat after oral administration of extract ofPotentilla discolorBunge by high-performance liquid chromatography/electrospray ionization mass spectrometry
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