Will the chemical probes please stand up?-Reference-Cited by-同舟云学术

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Will the chemical probes please stand up?

Published:2021 Issue:8 Volume:12 Page:1428-1441
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Škuta Ctibor¹^ORCID,Southan Christopher²^ORCID,Bartůněk Petr¹^ORCID

Affiliation:

1. CZ-OPENSCREEN, National Infrastructure for Chemical Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic

2. Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK

Abstract

This study provides a comprehensive and comparative overview of probe sources, structures and targets. The analysis encompasses 4466 chemical probe candidates supported by evidence of specific binding to 796 human proteins.

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Akademie Věd České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00138H

Reference63 articles.

1. Probe Reports from the NIH Molecular Libraries Program, National Center for Biotechnology Information (US) , Bethesda (MD) , 2010

2. The NIH Molecular Libraries Program: Identifying Chemical Probes for New Medicines

3. Database resources of the National Center for Biotechnology Information

4. A crowdsourcing evaluation of the NIH chemical probes

5. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

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