Palladium-catalyzed direct γ-C(sp<sup>3</sup>)–H arylation of β-alkoxy cyclohexenones: reaction scope and mechanistic insights-Reference-Cited by-同舟云学术

Palladium-catalyzed direct γ-C(sp³)–H arylation of β-alkoxy cyclohexenones: reaction scope and mechanistic insights

Published:2022 Issue:9 Volume:9 Page:2308-2315
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Shao Li-Dong¹^ORCID,Chen Yang¹,Wang Mei¹,Xiao Nan²,Zhang Zhi-Jun²^ORCID,Li Dashan¹,Li Rong-Tao²

Affiliation:

1. Yunnan Key Laboratory of Southern Medicinal Resources, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China

2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China

Abstract

Direct γ-C(sp3)-arylation of unactivated electron-rich enones remains a challenge. We have found a Pd-catalyzed method for direct γ-C(sp3)-arylation of unactivated β-alkoxy cyclohexenones which enables the synthesis of bioactive CBD-like compounds.

Funder

Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01871J

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