Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases-Reference-Cited by-全球学者库

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Published:2017 Issue:12 Volume:13 Page:2509-2520
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Prabhu Lakshmi¹²³^ORCID,Chen Lan⁴²³⁵⁶,Wei Han¹²³,Demir Özlem⁷⁸⁹¹⁰³,Safa Ahmad¹²³,Zeng Lifan⁴²³⁵⁶,Amaro Rommie E.⁷⁸⁹¹⁰³,O’Neil Bert H.¹¹⁶²³,Zhang Zhon-Yin⁵⁶²³^ORCID,Lu Tao¹²³⁵⁶

Affiliation:

1. Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive

2. Indianapolis

3. USA

4. Chemical Genomics Core Facility, Indiana University School of Medicine, 635 Barnhill Drive

5. Department of Biochemistry and Molecular Biology

6. Indiana University School of Medicine

7. Department of Chemistry and Biochemistry

8. University of California

9. San Diego

10. La Jolla

11. Department of Medicine, Indiana Cancer Pavilion

Abstract

The proposed workflow of the drug development pipeline with adapted AlphaLISA HTS-based screening to discover inhibitors of epigenetic targets like PRMT5 with possible significance in disease treatment.

Funder

Indiana Clinical and Translational Sciences Institute

V Foundation for Cancer Research

National Institute of General Medical Sciences

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MB/C7MB00391A

Reference16 articles.