Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway-Reference-Cited by-全球学者库

Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway

Published:2022 Issue:12 Volume:13 Page:6574-6582
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chu Shu-Chen¹,Hsieh Yih-Shou²³,Hsu Li-Sung⁴,Lin Chin-Yin²⁴,Lai Yi-An⁴,Chen Pei-Ni⁴⁵^ORCID

Affiliation:

1. Institute and Department of Food Science, Central Taiwan University of Science and Technology, Taichung, Taiwan

2. Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan

3. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

5. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Abstract

Cinnamaldehyde reduced the u-PA activity and invasiveness of the osteosarcoma cells by targeting the FAK pathway and reducing the expression of N-cadherin and fibronectin and suppressed the pulmonary metastasis of osteosarcoma in mice.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00634K

Reference37 articles.

1. Pathogenesis and Current Treatment of Osteosarcoma: Perspectives for Future Therapies

2. Osteosarcoma treatment – Where do we stand? A state of the art review

3. Primary Metastatic Osteosarcoma: Presentation and Outcome of Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

4. Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

5. Therapy for Osteosarcoma

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