Profiling humoral responses to COVID-19 immunization in Kawasaki disease using SARS-CoV-2 variant protein microarrays

Author:

Keskin Batuhan Birol1,Liu Shih-Feng234,Du Pin-Xian1,Tsai Pei-Shan1,Ho Tzong-Shiann567,Su Wen-Yu1,Lin Pei-Chun1,Shih Hsi-Chang8,Weng Ken-Pen910,Yang Kuender D.11,Huang Ying-Hsien12,Kuo Kuang-Che12,Syu Guan-Da11314ORCID,Kuo Ho-Chang3412

Affiliation:

1. Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Room 89A07, No. 1, University Road, Tainan 701, Taiwan

2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan

3. Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan

4. College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

5. Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China

6. Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan 701, Taiwan, Republic of China

7. Department of Pediatrics, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, Taiwan, Republic of China

8. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

9. Congenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan

10. School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan

11. MacKay Children's Hospital, Taipei 103, Taiwan

12. Kawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan

13. International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan 701, Taiwan

14. Medical Device Innovation Center, National Cheng Kung University, Tainan 701, Taiwan

Abstract

CoVariant arrays consist of spike variants of SARS-CoV-2. We profiled plasma neutralizing and binding antibodies in Kawasaki disease and healthy with unvaccinated, vaccinated, or infected with CoVariant arrays to compare their humoral responses.

Funder

Ministry of Health and Welfare

National Cheng Kung University

Kaohsiung Chang Gung Memorial Hospital

National Science and Technology Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference57 articles.

1. Molecular mechanisms of endothelial dysfunction in Kawasaki-disease-associated vasculitis

2. Kawasaki Disease: an Update

3. Kawasaki Disease in Infancy

4. The Centers for Disease Control and Prevention , About Kawasaki Disease , 2023 , https://www.cdc.gov/kawasaki/about.html

5. The epidemiology of Kawasaki disease: a global update

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