Enthalpy-driven nuclease-like activity and mechanism of peptide–chlorambucil conjugates-Reference-Cited by-同舟云学术

Enthalpy-driven nuclease-like activity and mechanism of peptide–chlorambucil conjugates

Published:2014 Issue:27 Volume:12 Page:4890-4904
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Robin C. K.¹²³,Huang Jonathan T. B.¹²³,Chen Yu-Ling¹²³,Hung Chia-Chun¹²³,Liao Mokai¹²³,Yao Wen-Chen¹²³,Chen Chiu-Heng¹²³,Liou Chien-Chung¹²³,Waring Michael J.⁴⁵⁶,Sheh Leung¹²³

Affiliation:

1. Department of Chemistry and Life Science Center

2. Tunghai Christian University

3. Taiwan 407, Republic of China

4. Department of Pharmacology

5. University of Cambridge

6. , UK

Abstract

The chemical nuclease activity, energetics, and stepwise cleavage mechanism of chlorambucil–peptide conjugates are presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00123K

Reference28 articles.

1. Chemical nucleases

2. Optimizing the Targeted Chemical Nuclease Activity of 1,10-Phenanthroline−Copper by Ligand Modification

3. Design of Sequence-Specific DNA-Binding Molecules

4. Distamycin and Penta-N-Methylpyrrolecarboxamide Binding Sites on Native DNA A Comparison of Methidiumproyl-EDTA-Fe(II) Footprinting and DNA Affinity Cleaving

5. DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and anticancer evaluation of novel oncolytic peptide-chlorambucil conjugates;Bioorganic Chemistry;2023-09

2. Peptide Targeting Methods;Handbook of In Vivo Chemistry in Mice;2019-12-27

3. Improvement of Stability and Anticancer Activity of Chlorambucil-Tetrapeptide Conjugate Vesicles;Chinese Journal of Chemistry;2016-03-29

4. Advancement and applications of peptide phage display technology in biomedical science;Journal of Biomedical Science;2016-01-19

5. Editorial (Thematic Issue: Potential Therapeutic Agents based on DNA Sequence- Selective Binding Substances);Current Topics in Medicinal Chemistry;2015-05-08