Localized temporal co-delivery of interleukin 10 and decorin genes using amediated by collagen-based biphasic scaffold modulates the expression of TGF-β1/β2 in a rabbit ear hypertrophic scarring model-Reference-Cited by-同舟云学术

Localized temporal co-delivery of interleukin 10 and decorin genes using amediated by collagen-based biphasic scaffold modulates the expression of TGF-β1/β2 in a rabbit ear hypertrophic scarring model

Published:2021 Issue:8 Volume:9 Page:3136-3149
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

McArdle Ciarstan¹²³⁴,Abbah Sunny Akogwu¹²³⁴^ORCID,Bhowmick Sirsendu¹²³⁴^ORCID,Collin Estelle¹²³⁴,Pandit Abhay¹²³⁴^ORCID

Affiliation:

1. CÚRAM

2. SFI Research Centre for Medical Devices

3. National University of Ireland Galway

4. Ireland

Abstract

The study shows that although pIL-10/pDCN therapy are individually able to suppress TGF-β1/β2, only the combined overexpression of both transgenes was efficacious in suppressing TGF-β1/β2 and concurrently sustaining the upregulation of TGF-β3.

Funder

Science Foundation Ireland

H2020 Marie Skłodowska-Curie Actions

Irish Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01928C

Reference97 articles.

1. Abstract 175