Synthesis of imidazo[1,2-a]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology

Author:

Wei Minghui1,Chen Jiankun1,Liu Chengkou1,Yang Zhao2,Qin Hong1,Hu Yujing1,Duan Jindian1,Li Yuguang3,Fang Zheng14ORCID,Guo Kai14ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University, 30 Puzhu Rd S., Nanjing, 211816, China

2. College of Engineering, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210003, China

3. Institute of Nanjing Advanced Biomaterials & Processing Equipment, China

4. State Key Laboratory of Materials-Oriented Chemical Engineering, 30 Puzhu Rd S., Nanjing, 211816, China

Abstract

We successfully developed an unprecedented route for imidazo[1,2-a]pyridinone synthesis through a visible light-photocatalysed functionalization of alkynes/nitrile insertion/cyclization tandem sequence in a microchannel reactor.

Funder

National Natural Science Foundation of China

Jiangsu National Synergistic Innovation Center for Advanced Materials

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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